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Little Italy may be disintegrating by the second, but there will be no shortage of Italian, family-owned stores if Madison Avenue has anything to do with it. This brand's first outpost in the U.S. mirrors the original Italian boutique with a modest interior displaying its tailored, conservative apparel for both men and women. Simply smelling these garments takes you one step closer to Naples, where they're made. Negri's son, Gian Luigi, recommends the line's best Florentine sellers--a black and white striped pop collar dress with a belt ($535) and a Euro-style double button men's cotton shirt in blue and white stripes ($250).

Find more shops at Time Out New York.